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1994-10-25
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Document 2957
DOCN M94A2957
TI Human papilloma virus in the esophagus in HIV patients.
DT 9412
AU Bouchaud O; Marche C; Cadiot G; Longuet P; Rene E; Coulaud JP; Bichat
Claude Bernard Hospital, Paris, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):186 (abstract no. PB0171). Unique
Identifier : AIDSLINE ICA10/94369618
AB OBJECTIVE: Esophagitis (E) in AIDS patients (pts) remain frequently
without etiology. We would like to show that Human Papillomavirus (HPV)
may be found in the esophagus and to discuss HPV as a possible agent in
E. METHODS: We performed a prospective study in pts having had an upper
endoscopy. Pts were divided in 3 groups: grp 1 = no lesion in the
esophagus, grp 2 = non ulcerated E, grp 3 = ulcerated E. Standard
histologic examination, immuno-markers study and in situ hybridization
(ISH) were performed. In case of positivity of ISH-HPV, confirmation and
typing by PCR was available. RESULTS: We included 103 pts: 32 in grp 1,
36 in grp 2, 35 in grp 3. Among them 75 were AIDS, 21 ARC and 4
asymptomatic. Mean CD4 count was 76/mm3 (4-766). HPV was found in 31% of
cases and respectively in 34% (grp1), 33% (grp2), 27% (grp3). There was
no specific risk factor associated with HPV. In 18 cases it was the only
pathogen found. Confirmation by PCR was always positive. In HPV+ pts,
mean CD4 count was 113/mm3 (4-766) whereas in HPV- pts mean CD4 count
was 59/mm3 (4-485); p < 0.05. CONCLUSION: 1) this is the first report of
HPV in the esophagus in HIV pts. 2) because it is found both in
esophagus with or without lesion, HPV is probably not an etiologic agent
in E but could be a co-factor. 3) HPV seems to be associated with an
immune status less deficient than in pts without HPV.
DE AIDS-Related Opportunistic Infections/*PATHOLOGY Endoscopy,
Gastrointestinal Esophagitis/*PATHOLOGY Esophagus/PATHOLOGY Human
*Papillomavirus, Human/ISOLATION & PURIF Papovaviridae
Infections/*PATHOLOGY Polymerase Chain Reaction Prospective Studies
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).